TABLE 1.  Major clinical manifestations of liver disease (asterisk implies chronicity)
Systemic
  • Anorexia, malaise, fatigue
  • Fever
  • *General deterioration, weight loss, "cirrhotic habitus"
  • Cholestasis: pruritus, *xanthelasma/xanthomas, *malabsorption problems

    Jaundice

    		•
    Hepatomegaly ± pain
    Portal hypertension
    Fluid derangements
  • *Ascites ± edema
  • Electrolyte disturbances
  • Functional renal failure ("hepatorenal syndrome")
    		•
    Hepatic encephalopathy (portal-systemic encephalopathy)
    *Cutaneous and endocrine changes
  • Spider nevi, palmar erythema, Dupuytren's contractures
  • Gynecomastia, testicular atrophy, impotence
  • Amenorrhea
  • Parotid enlargement
    		•
    Coagulopathy
  • Hypoprothrombinemia
  • Thrombocytopenia
  • Dysfibrinogenemia
    		•
    Circulatory changes
  • Hyperdynamic circulation
  • *Arterial desaturation, clubbing
    		•