TABLE 23.  Liver transplantation: indications

1. Chronic liver disease

Cholestatic disorders Primary biliary cirrhosis Primary sclerosing cholangitis Drug-induced cholestasis and biliary cirrhosis

Hepatocellular disease Chronic viral hepatitis (B ± D, HCV, non-A non-B) Chronic drug-induced liver disease Alcoholic liver disease Autoimmune liver disease Wilson's disease, hemochromatosis, a1-antitrypsin deficiency

Vascular disease Budd-Chiari syndrome Veno-occlusive disease

2. Fulminant hepatic failure

Viruses HAV, HBV, (HCV), HDV, HEV, non A-E HSV, EBV, CMV, HZV, etc.

Drugs and toxins Acetaminophen, NSAIDs, isoniazid, etc. Industrial substances, mushrooms

Other etiologies Metabolic disorders Hypoperfusion Microvesicular steatosis Autoimmune hepatitis "Surgical" causes

3. Hepatic malignancies (unresectable, confined to liver)

4. Inherited genetic and metabolic disorders